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. 2022 Apr 22;100(5):781–795. doi: 10.1007/s00109-022-02184-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Inhibition of p38 MAPK does not alter development of hyperglycemia but prevents hyperglycemia-induced albuminuria. a Blood glucose levels of normoglycemic (control), hyperglycemic (STZ), and hyperglycemic mice treated with p38 MAPK inhibitor (STZ + SB202190) at day 1 and day 5. Glucose levels day 5: control (n = 11) vs. STZ (n = 14): 161.0 ± 5.6 vs. 341.6 ± 25.3 mg/dL (****p < 0.0001); STZ (n = 14) vs. STZ + SB202190 (n = 16): 341.6 ± 25.3 vs. 302.1 ± 18.8 mg/dl (p = ns). b Molecular mass markers are indicated in kilodalton (kDa), SDS-PAGE/Coomassie gel staining of urine (day 5) in normoglycemic (control), hyperglycemic (STZ), and hyperglycemic mice treated with p38 MAPK inhibitor (STZ + SB202190). BSA at 1, 5, and 10 µg/µL served both as a control and standard. c Quantitative analysis of the urinary albumin to creatinine ratio (UACR) (day 5) in normoglycemic (control), hyperglycemic (STZ), and hyperglycemic mice treated with p38 MAPK inhibitor (STZ + SB202190). UACR day 5: control (n = 18) vs. STZ (n = 15) 15.6 ± 3.0 vs. 152.9 ± 14.3 mg/g (****p < 0.0001); STZ (n = 15) vs. STZ + SB202190 (n = 8): 152.9 ± 14.3 vs. 53.5 ± 4.7 mg/g (****p < 0.0001)