Table 2.
Study characteristics of all cause and cause-specific mortality in ankylosing spondylitis
| Author, year | Geographic location | Study design (data source) | Study period (total duration in years with follow up) | Population | No. of patients | Definition of cases | No. of AS patients | Comparison group | Mean Age (year) | Female (%) |
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| All-cause mortality | ||||||||||
| Mok et al. 2011 [32] | Hong Kong | Population- Based, Retrospective cohort (CDARS - outpatient clinics and inpatient admissions) | 1999–2008 (9) | NR | 18627 | ICD -9 | 2154 | General population | 51.7 +/−13.2 | 46 |
| Bakland et al. 2011 [26] | Tromsø and Finnmark counties, Norway | Retrospective, single hospital cohort (University Hospital of Northern Norway) | 1977–2009 (32) | 18+ | 677 | Modifed New York Criteria | 677 | General Population | 23.2+/−8.5 | 24.5 |
| Wright et al. 2015 [27] | Olmsted County, MN, USA | Population-based retrospective cohort (Rochester Epidemiology Project) | 1980–2009 (31) | 18+ | 86 | Modified New York Criteria | 86 | General Population | 34.9+/–9.9 | 34.5 |
| Exarchaou et al. 2016 [34] | Sweden | Population-based, retrospective cohort (National patient registry) | 2006–2012 (12) | 18+ | 8600 | ICD-code | 8600 | General Population | 49.3 | 34.5 |
| Dregan et al. 2017 [30] | UK | Population-based, prospective cohort (UK biobank data) | 2006–2010 (4) | NR | 19082 | Clinical diagnosis | 1400 | General Population | 37 | 38 |
| Bae et al. 2019 [25] | Korea | Population-based, retrospective cohort (National health insurance database) | 2010–2014 (5) | 20+ | 12988 | Medical Expenses for Rare Complaints Code, V14.0, ICD-10 | 15,547 | General Population | 40 +/− 14.2 | 27.6 |
| Cardiovascular-related mortality | ||||||||||
| Haroon et al. 2015 [31] | Ontario, Canada | Population-based, retrospective cohort (Provincial health database; Ontario registrar database) | 1995–2011 (16) | 15+ | 108079 | ICD9-CM 720 | 21,164 | General Population | 45.6 | 47 |
| Dregan et al. 2017 [30] | UK | Population-based, prospective cohort (UK biobank data) | 2006–2010 (4) | - | 19082 | Clinical diagnosis | 1400 | General Population | 37 | 38 |
| Prati et al. 2017 [33] | France | Population-based retrospective cohort (National death registry) | 1969–2009 (40) | 18+ | 1969 | ICD-8 712.4 | 2940 | General Population | 60.1 | 22 |
ICD= International Classification of Disease, CDARS= Clinical Data Analysis and Reporting System, THIN= The Health Improvement Network, NR= not reported.