Figure 1.

Baseline correlations between plasma biomarkers and age, vital signs, laboratory measures, cognitive test scores, and structural MRI measures

For age, values represent Spearman’s rank correlation for each biomarker. For all other variables, values represent a partial Spearman’s correlation adjusting for age (top panel), or adjusting for age and eGFR (bottom panel). BMI denotes body mass index, eGFR estimated glomerular filtration rate based on the CKD-EPI equation, HDL high density lipoprotein, UACR urine albumin to creatinine ratio, MoCA Montreal Cognitive Assessment, and WML white matter lesion. The memory composite domain score consisted of scores from the HVLT-R immediate and delayed recall, the ROCFm immediate recall, and Logical Memory I and II; Processing speed included the TMT-Parts A and B and Digit Symbol Coding; Executive function included the TMT – Part B minus Part A and Digit Span; Language included the Boston Naming and Category Fluency; and global cognitive function consisted of all tests included in the above domain scores. *** denotes P value<0.001, ** P value<0.01, and * P value<0.05.