Figure 3.

Association of intensive treatment versus standard treatment on follow-up plasma biomarkers as a function of baseline levels

Estimates based on linear model for follow-up plasma biomarker levels, adjusted for time since randomization, including an interaction between baseline levels and treatment group, with the effect of baseline levels modeled using cubic splines. Lines represent estimated treatment group difference at 3.81 years post-randomization (intensive treatment minus standard treatment) with associated 95% simultaneous confidence bands.