Table 1.
Baseline characteristics of participants in the blood biomarker sub-study by treatment group
| Characteristic | Intensive Treatment N = 283 |
Standard Treatment N = 234 |
|---|---|---|
|
| ||
| Age, years, mean (SD) | 69.8 (6.9) | 69.9 (7.4) |
| Age ≥ 75 years, No. (%) | 82 (29.0) | 65 (27.8) |
|
| ||
| Female sex, No. (%) | 126 (44.5) | 96 (41.0) |
|
| ||
| Race/Ethnicity, No. (%) | ||
| White | 192 (67.8) | 152 (65.0) |
| Black | 81 (28.6) | 65 (27.8) |
| Hispanic | 6 (2.1) | 14 (6.0) |
| Other | 4 (1.4) | 3 (1.3) |
|
| ||
| History of Cardiovascular Disease, No. (%) | 42 (14.8) | 37 (15.8) |
|
| ||
| Systolic Blood Pressure, mm Hg, mean (SD) | 138.0 (17.6) | 138.7 (15.9) |
|
| ||
| Diastolic Blood Pressure, mm Hg, mean (SD) | 75.7 (10.5) | 77.0 (12.3) |
|
| ||
| eGFR, ml/min/1.73 m2, mean (SD) | 71.1 (19.0) | 70.1 (18.0) |
| eGFR<60 ml/min/1.73 m2 | 77 (27.9) | 74 (32.0) |
|
| ||
| Urine Albumin to Creatinine Ratio, mg/g, median [IQR] | 9.4 [5.3 to 21.3] | 9.9 [6.2 to 20.4] |
|
| ||
| Use of Statin, No. (%) | 125 (44.3) | 109 (47.2) |
|
| ||
| Use of Aspirin, No. (%) | 156 (55.1) | 131 (56.0) |
|
| ||
| Montreal Cognitive Assessment, median [IQR]a | 24 [21 to 26] | 24 [21 to 27] |
|
| ||
| Logical Memory II, median [IQR]b | 9 [6.5 to 12] | 8 [6 to 11] |
|
| ||
| Digit Symbol Coding, median [IQR]c | 52 [43. to 60] | 52 [41 to 62] |
|
| ||
| Total Brain Volume, cm3, mean (SD) | 1124.7 (116.8) | 1133.4 (114.4) |
|
| ||
| WML Volume, cm3, median [IQR] | 3.6 [1.7 to 7.5] | 3.9 [2.0 to 6.8] |
|
| ||
| Aβ40, pg/ml, median [IQR] | 194.9 [133.9 to 277.5] | 186.0 [123.1 to 267.5] |
|
| ||
| Aβ42, pg/ml, median [IQR] | 21.0 [16.2 to 26.4] | 21.6 [16.5 to 28.8] |
|
| ||
| Aβ42 / Aβ40, median [IQR] | 0.10 [0.07 to 0.15] | 0.10 [0.08 to 0.22] |
|
| ||
| Total Tau, pg/ml, median [IQR] | 7.7 [6.3 to 9.3] | 8.1 [6.1 to 9.7] |
|
| ||
| Neurofilament Light Chain, pg/ml, median [IQR] | 13.7 [9.3 to 20.1] | 14.9 [8.6 to 23.4] |
eGFR denotes estimated glomerular filtration rate based on the CKD-EPI equation, IQR Interquartile Range, SD Standard Deviation, and WML White Matter Lesion.
a
Scores range from 0 to 30, with higher scores denoting better cognitive function.
b
Subtest of the Wechsler Memory Scale. Scores range from 0 to 14, with higher scores denoting better cognitive function.
c
Subtest of the Wechsler Adult Intelligence Scale. Scores range from 0 to 135, with higher scores denoting higher cognitive function.