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Source and site of activity of anticoagulant SERPINs. Anticoagulant SERPINs AT, HCII, PZPI, C1INH, and PCI are present in the plasma whereas PN1 is stored in platelet alpha granules where it can be released on platelet activation. Anticoagulant SERPINs bind to glycosaminoglycans (GAGs) or protein cofactors on the endothelial surface that potentiate inhibition of target proteases. Created with BioRender.com.
