TABLE 1.

Anticoagulant SERPINs and targets.

Protein	Gene	Molecular weight (kDa)	Coagulation targets	Rate constant (M–1 s–1)	References	Non-coagulation targets	Rate constant (M–1 s–1)	References
A1AT	SERPINA1	53	FXa FXIa	1.3 × 102 1.0 × 102	(207) (37)	NE PR3 CG	1.3 × 107 8.1 × 106 4.1 × 105	(208) (206) (204)
PCI	SERPINA5	46	FIIa aPC FXIa PKa FXa	2.4 × 106 tm 1.5 × 106 h 7.4 × 105 h 1.8 × 105 h 9.0 × 104 h	(192) (191) (191) (191) (191)
PZPI	SERPINA10	72	FXIa FIXa FXa	7.7 × 105 h 5.4 × 105 3.6 × 105 h	(114) (116) (114)
AT	SERPINC1	58	FIIa FXa FIXa PKa FXIa	6.1 × 107 h 4.4 × 107 h 9.0 × 106 h 1.9 × 105 h 1.5 × 103 ds	(41) (41) (266) (267) (37)
HCII	SERPIND1	65	FIIa FXa	4.5 × 108 h 3.0 × 105 h	(83) (83)
PN1	SERPINE2	50	FIIa FXIa FXa	1.2 × 109 h 1.7 × 106 h 3.5 × 105 h	(173) (174) (173)	Trypsin uPA Plasmin	1.0 × 107 h 9.6 × 105 1.0 × 105 h	(173) (173) (173)
C1INH	SERPING1	105	PKa FXIIa FXIa FIIa	2.9 × 106 4.3 × 105 2.1 × 105 ds 1.3 × 104	(268) (269) (37) (270)	C1r C1s Plasmin tPA	NR 3.4 × 105 NR NR	(244)

ds, in the presence of dermatan sulfate; h, in the presence of heparin; tm, in the presence of thrombomodulin. NR, not reported.