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. 2022 May 17;12:178. doi: 10.1038/s41398-022-01943-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Experimental timeline for behavioral testing after intra-mPFC infusion of either control IgG (160 ng/side) or IGF-1 nAb (160 ng/side) and i.p. injection of either saline or ketamine (10 mg/kg). b Immobility time in the forced swim test (FST) 1 day after intra-mPFC and i.p. injections (interaction, F_1,40 = 15.7, p = 0.0003, n = 11). c Locomotor activity (LMA) 2 days after intra-mPFC and i.p. injections (interaction, F_1,40 = 0.0610, p = 0.806, n = 11). d Time spent sniffing female urine in the female urine sniffing test (FUST) 3 days after intra-mPFC and i.p. injections (interaction, F_1,40 = 5.36, p = 0.0259, n = 11). e Latency to feed in the novelty-suppressed feeding (NSF) test 4 days after intra-mPFC and i.p. injections (interaction, F_1,40 = 4.18, p = 0.0475, n = 11). f Home cage feeding (HCF) just after the NSF (interaction, F_1,40 = 0.281, p = 0.101, n = 11). g Schematic representation of mPFC infusion sites. Plates are from ref. [50]; 1.94, 1.78, 1.70, and 1.54 indicate distances (mm) from bregma. Data are expressed as means ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 (two-way ANOVA followed by Holm–Sidak’s post hoc test).