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Organoids for cancer research. Non-tumoral organoids derived from healthy or normal-like tissue adjacent to tumor (A) or from pluripotent stem cells (B) have been engineered to study the role of PDAC driving mutations. (C) Tumoral organoids in mono- or co-cultures are used as model for drug testing. * (Lee et al., 2017) § (Seino et al., 2018) Δ (Huang et al., 2021), δ (Breunig et al., 2021).
