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. Author manuscript; available in PMC: 2022 Aug 17.
Published in final edited form as: Cell Rep. 2021 Aug 17;36(7):109522. doi: 10.1016/j.celrep.2021.109522

Figure 5. PC-specific loss of Tie2 leads to alterations in the expression of genes involved in neuronal wiring.

Figure 5.

(A) The PC translatome was sequenced form Pcp2Cre:Rpl22HA/HA and Pcp2Cre:Tie2flox/flox:Rpl22HA/HA animals at P56. The top 100 gene changes (by adjusted p value) are shown ranked by unmodified log2 fold change.

(B) Shortened list of affected pathways analyzed with ingenuity pathway analysis (IPA).

(C–F) Among annotations, “organization of cytoskeleton” (C and D) and “branching of neurites” (E and F) are shown. Total gene changes (IfcShrink fold change) are visualized by volcano plot in (C) and (E). The top 100 up- and downregulated genes of the annotations are shown ranked by unmodified log2 fold change in (D) and (F).

See also Figure S7.