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. 2022 May 3;10:850708. doi: 10.3389/fcell.2022.850708

FIGURE 6.

FIGURE 6

CircFGGY inhibits the growth and metastasis of HCC through the miR-545-3p/Smad7 axis in vitro. (A–C) The cell proliferation (A), migration (B) and invasion (C) decreased after the overexpression of circFGGY, and these processes were reversed after overexpression of miR-545-3p in MHCC97H or HepG2 cells. Scale bar, 500 µm (B), 100 µm (A,C). (D) The mRNA expression of Smad7 was upregulated after overexpression of circFGGY, and the expression was reversed after overexpression of miR-545-3p in MHCC97H cells. (E) Western blot detected the protein expression of Smad7 and the biomarkers of EMT after the overexpression of circFGGY or circFGGY/miR-545-3p in MHCC97H cells. One-Way ANOVA was used (A–E). Data are represented as mean ± SD, n = 3. Comparing with Ov-circFGGY + NC-mimic group, *: p < 0.05; **: p < 0.01; ***: p < 0.001.