Fig. 3.

SARS‐CoV‐2 NSP1 interferes with the host antiviral responses. (Left) The entry of SARS‐CoV‐2 in the cytoplasm of the infected cell introduces double‐stranded RNA (dsRNA) that triggers the activation of innate immune pathways that lead to the production of type I interferon IFN‐α and ‐β which are secreted by the infected cell. (Right) The produced type I interferons will then activate, through a cascade of phosphorylations, the antiviral response by stimulating the expression of IFN‐Stimulated Genes (ISGs). The SARS‐CoV‐2 viral protein NSP1 shuts down the antiviral response by interfering with multiple steps of this pathway (the steps inhibited by NSP1 are shown in red).