Table 4.
Composite outcome: Death, ICU admission, and mechanical ventilation
| Variable | 0 (N = 206) | 1 (N = 74) | Average marginal effect (AME) | p | Lower | Upper |
|---|---|---|---|---|---|---|
| CAC | 48% | 57% | 0.067 | .247 | −0.0464 | 0.1805 |
| Age | 51.250/61.850/75.025 | 58.075/68.650/76.675 | 0.0049 | <.001 | 0.0022 | 0.0075 |
| Male sex | 65% | 76% | −0.0947 | .077 | −0.1999 | 0.0104 |
| Hypertension | 44% | 68% | 0.1819 | <.001 | 0.0801 | 0.2838 |
| Diabetes | 22% | 24% | 0.0276 | .666 | −0.0979 | 0.1532 |
| Smoking | 14% | 24% | 0.151 | .046 | 0.003 | 0.299 |
| Obesity | 20% | 18% | −0.0205 | .7703 | −0.1583 | 0.1172 |
| Dyslipidemia | 26% | 42% | 0.1497 | .016 | 0.0278 | 0.2715 |
| WBC | 3.7400/4.9000/6.7300 | 3.7950/5.4800/10.7375 | 0.0121 | .067 | −0.0009 | 0.0252 |
| Creatinine (mg/dl) | 0.720/0.800/1.065 | 0.760/0.920/1.300 | −0.0044 | .475 | −0.0165 | 0.0077 |
| CRP admission (mg/L) | 16.00/50.50/87.25 | 59.25/100.00/157.50 | 0.0021 | <.001 | 0.0013 | 0.0029 |
| Procalcitonin | 0.0400/0.0600/0.1500 | 0.0800/0.2300/0.4600 | 0.0397 | .43 | −0.0589 | 0.1383 |
| Saturation O2 | 94/96/97 | 88/92/95 | −0.0276 | .001 | −0.0439 | −0.0113 |
| Consolidation | 61% | 79% | 0.1665 | .001 | 0.0713 | 0.2617 |
| GGO | 79% | 90% | 0.1555 | .014 | 0.0311 | 0.28 |
| Bilateral infiltration | 83% | 96% | 0.2184 | <.001 | 0.1167 | 0.3201 |
| Antibiotics | 93% | 100% | 0.2727 | <.001 | 0.2308 | 0.3147 |
| Antiviral | 36% | 35% | −0.014 | .815 | −0.1316 | 0.1035 |
| Hydroxychloroquine | 35% | 22% | −0.1108 | .029 | −0.2103 | −0.0113 |
| Corticosteroids | 52% | 78% | 0.2044 | <.001 | 0.0968 | 0.312 |
| Tocilizumab | 6% | 6% | −0.0095 | .941 | −0.2635 | 0.2444 |
| Plasma | 14% | 22% | 0.1243 | .119 | −0.0321 | 0.2808 |
| d‐dimer 500–1000 | 14% | 22% | 0.1585 | .054 | −0.0029 | 0.3199 |
| d‐dimer >1000 | 7% | 23% | 0.3433 | <.001 | 0.1654 | 0.5211 |
| Peak HScTnI 34‐200 | 10% | 24% | 0.3155 | .002 | 0.1205 | 0.5105 |
| Peak HScTnI>200 | 3% | 30% | 0.6375 | <.001 | 0.4735 | 0.8014 |
| Previous CAD | 8% | 15% | 0.1398 | .1938 | −0.0711 | 0.3508 |
| Chronic kidney disease | 8% | 13% | 0.114 | .2753 | −0.09083 | 0.3189 |
| Peripheral vasculopathy | 7% | 16% | 0.1842 | .07392 | −0.01782 | 0.3862 |
| Pulmonary Hypertension | 0% | 1% | ||||
| Chronic broncopneumopathy | 3% | 10% | 0.2568 | .03475 | 0.0184 | 0.4951 |
| Previous malignancy | 9% | 11% | 0.05769 | .4664 | −0.09756 | 0.2129 |
| Active malignancy | 9% | 11% | 0.05769 | .5073 | −0.1128 | 0.2282 |
| Multivariate analysis: Data are AME, p (p‐value), and lower and upper bound of the 95% confidence Interval | ||||||
| Variable | AME | p | Lower | Upper |
|---|---|---|---|---|
| Antibiotic | 0.2865 | <.001 | 0.2258 | 0.3472 |
| CRP | 0.0013 | <.001 | 0.0007 | 0.0018 |
| Peak HScTnI 34–200 | 0.2439 | .005 | 0.0737 | 0.4140 |
| Peak HScTnI>200 | 0.4801 | <.001 | 0.2891 | 0.6711 |
| Saturation O2 | −0.0154 | .022 | −0.0286 | −0.0023 |
| Chronic broncopneumopathy | 0.2568 | .03475 | 0.0184 | 0.4951 |
Note: Data are percentages for categorical variables and I quartile/median/III quartile for continuous variables. The table also reports the results of the univariable models, as AME, p (p‐value), and lower and upper bound of the 95% confidence Interval.
Abbreviations: CAC, coronary artery calcium; CAD, coronary artery disease; CRP, C‐reactive protein; GGO, ground‐glass opacification; HScTnI, high‐sensitivity cardiac troponin I; ICU, intensive care unit; WBC, white blood count.