TABLE 3.

Repeated measure multivariate analysis of repeated measurements (MANOVA) of immune biomarkers and Wisconsin scale (WIS) between the baseline, and 2 weeks after the intervention, and 1 week as a follow‐up

	Group	Baseline	After 2 Weeks			Follow‐up
		M±SD	MD±SD	95%CI	p	MD±SD	95%CI	p
Wisconsin scale	Control	110.3 ± 5.64	104.27 ± 5.85	4.61, 7.39	>0.01*	105.67 ± 5.51	3.48, 5.72	>0.01*
	Intervention	106.73 ± 5.42	91.27 ± 4.73	13.45, 17.48	>0.01*	91.80 ± 8.36	10.65, 19.22	>0.01*
Leucocytes, ×109/L	Control	5.267 ± 1.37	5.84 ± 1.43	0.46, 0.68	>0.01*	5.66 ± 1.45	0.26, 0.52	>0.01*
	Intervention	5.4667 ± 1.30	7.3847 ± 1.43	1.69, 2.15	>0.01*	7.21 ± 1.54	1.45, 2.03	>0.01*
Lymphocytes, ×109/L	Control	0.93 ± 0.31	1.29 ± 0.23	0.20, 0.54	>0.01*	1.23 ± 0.23	0.15, 0.45	0.01*
	Intervention	0.9367 ± 0.30	2.0933 ± 0.21	0.99, 1.32	>0.01*	1.88 ± 0.30	0.75, 1.14	>0.01*
Interleukin‐6, pg/mL	Control	22.73 ± 11.53	23.01 ± 11.45	−0.07, 0.61	0.11	22.95 ± 11.40	−0.10, 0.52	0.16
	Intervention	23.01 ± 11.60	26.90 ± 11.83	3.20, 4.50	>0.01*	26.67 ± 11.90	3.01, 4.24	>0.01*
Interleukin‐10, pg/mL	Control	6.16 ± 1.15	6.31 ± 1.169	0.026, 0.27	0.02*	6.27 ± 1.170	0.01, 0.21	0.03*
	Intervention	6.17 ± 1.11	7.05 ± 1.055	0.72, 1.05	>0.01*	6.96 ± 1.03	0.61, 0.97	>0.01*
Immunoglobulin A, g/L	Control	2.20 ± 0.37	2.39 ± 0.51	0.06, 0.31	0.07	2.38 ± 0.50	0.053, 0.30	0.08
	Intervention	2.32 ± 0.39	3.42 ± 0.34	0.89, 1.33	>0.01*	3.22 ± 0.35	0.72, 1.09	>0.01*
TNF‐α	Control	10.23 ± 0.79	10.23 ± 0.79	0.00, 0.01	0.13	10.23 ± 0.79	0.00, 0.01	0.22
	Intervention	10.57 ± 0.56	10.57 ± 0.56	0.00, 0.01	0.07	10.57 ± 0.56	0.00, 0.01	0.13

Abbreviations: CI, confidence interval; M, mean; p, probability; SD, standard deviation; *, significant.