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. 2022 May 13;219(6):e20201405. doi: 10.1084/jem.20201405

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Figure 7. — GIMAP6 is expressed in immune cells and is inducible by IFN-γ stimulation. (A) WB analysis of GIMAP family members and HSP90 (control) proteins in the indicated tissues from healthy donors. SI, small intestine. Shown is one of two experiments. (B) WB analysis of GIMAP family members and HSP90 (control) proteins in the indicated immune cell populations isolated from human PBMCs. Shown is one of four experiments. (C) Quantitative PCR analysis of fold-change of GIMAP6 mRNA expression over unstimulated condition in THP-1 differentiated macrophages after stimulating with IFNs (100 ng/ml) or LPS (1 µg/ml) for the indicated hours. Data are pooled from three experiments. Bars represent mean ± SEM. An unpaired t-test was used (**, P < 0.01; ***, P < 0.001). (D) WB analysis of GIMAP and GAPDH (control) proteins in THP-1 cells after stimulating with IFNs (100 ng/ml) or LPS (1 µg/ml) at the indicated times. Shown is one of three experiments.