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. 2022 Apr 8;32(5):e2347. doi: 10.1002/rmv.2347

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© 2022 John Wiley & Sons Ltd.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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SARS‐CoV‐2 neutralising monoclonal antibodies (MAbs) grouped based on targeting regions of the spike protein. SARS‐CoV‐2 trimeric spike protein is illustrated showing S1 domain regions: the N‐terminal domain (NTD) (salmon), Receptor binding domain (RBD) (slate), receptor‐binding motif (RBM) (bright orange), SD1 (palegreen), and SD2 (yellow) and S2 domain regions: Upstream helix (UH) (violet), Fusion peptide (FP) (aquamarine), HR1 (blue), SD3 (orange) and Stem helix (SH) (red). SARS‐CoV‐2: Severe acute respiratory syndrome coronavirus 2, S: Spike; NTD: N‐terminal domain; RBD: Receptor binding domain; RBM: Receptor‐binding motif, SD: Subdomain; UH: Upstream helix; FP: Fusion peptide; HR: Heptad repeat; SH: Stem helix; TM: Transmembrane; CT: Cytoplasmic tail