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. 2022 Mar 13;2(6):2100124. doi: 10.1002/smsc.202100124

Figure 1.

Figure 1

Screening for 3CLpro inhibitors based on the thermal shift assay. a) Eight compounds shift the melting temperature of 3CLpro by >3.0 °C and are considered as positive hits among 237 tested compounds. Black points within gray dashed lines represent negative hits. b) Verification of the inhibitory effect of eight positive hits from TSA versus the DMSO control (n = 2 independent replicates, p = 0.0081, 0.0015, and 0.0032 for EGCG, Oridonin, and SAA, respectively; not significant p > 0.05, * p < 0.05, and ** p < 0.01).