Figure 7.

Covalent binding inhibitors of 3CLpro and their electrophilic group. Oridonin and other reported covalent binding inhibitors. The red functional groups represent the electrophilic groups that covalently bind to Cys145, and the light‐yellow circles represent the atomic sites that form the covalent bond. a,b) The aldehyde group of 11a and 11b. c,d) The carbonyl group of Boceprevir and Carmofur. e) The pyrogallol group of Myricetin. f) The acyclic peptide structure α,β‐unsaturated ester group of N3. g) The aldehyde precursor group of GC376. h) The α,β‐unsaturated olefin group of Oridonin.