FIGURE 1.

Humoral immune response after a third mRNA vaccine dose in kidney transplant recipients and healthy controls as determined by commercially available assays. (A) Anti-spike IgG (left panel), surrogate neutralizing (middle panel), and anti-receptor-binding domain (right panel) antibodies in 49 kidney transplant recipients and 25 age-matched healthy controls after a third mRNA vaccine dose. The dashed red line indicates the respective cut-off for each assay. (B) IgG antibodies against the SARS-CoV-2 full spike, spike S1, and spike S2 subunits in 49 kidney transplant recipients and 25 age-matched healthy controls. The y-axis represents the mean fluorescence intensity (MFI) where the dashed red line indicates the cut-off for each target. (C) Seropositivity for anti-spike IgG, surrogate neutralizing, and anti-receptor-binding domain antibodies in 49 kidney transplant recipients and 25 age-matched healthy controls after a third mRNA vaccine dose shown in a Venn diagram. HC, healthy controls; KTR, kidney transplant recipients; MFI, mean fluorescence intensity; N, number; RBD, receptor-binding domain; snABs, surrogate neutralizing antibodies. ***p< .001 [Color figure can be viewed at wileyonlinelibrary.com]