TABLE 1.

Multivariate analysis of clinical factors independently associated with the primary outcome of death or intensive care unit admission in patients hospitalized due to COVID‐19

Variable	Death or ICU admission within 30 days
Variable	Logit coefficient	SE	OR	SE
Wave 1	−0.484	0.281	0.616	0.18
Age	0.183 ^**	0.00063	1.018 ^**	0.00662
Weight (kg)	−0.00937 ^*	0.00419	0.991 ^*	0.00427
Female	−0.335 ^*	0.155	0.715 ^*	0.114
White	0.194	0.157	1.02	0.171
Diabetes	−0.289	0.229	0.749	0.174
Stroke	−0.0506	0.224	0.951	0.216
Heart disease (IHD +/− CCF)	0.413 ^*	0.178	1.511 ^*	0.289
Hypertension	−0.0461	0.163	0.955	0.159
Admission eGFR	−0.0157 ^**	0.00303	0.984 ^**	0.0031
FiO ₂ (maximum during admission)	0.0711 ^**	0.00927	1.074 ^**	0.0104
Dexamethasone usage—patients without diabetes	−0.854 ^*	0.349	0.426 ^*	0.149
Dexamethasone usage—patients with diabetes	−0.786 ^*	0.357	0.456 ^*	0.174
Remdesivir	−0.0995	0.201	0.905	0.186
Tociluzimab	−0.12	0.453	0.887	0.39
Residual FiO₂	−0.00951	0.00942
Constant	−3.254^**	0.723

Note: Unselected multivariate logistic (Logit) analysis of clinical variables that were collected for patients admitted with swab positive COVID‐19 in Wave 1 and Wave 2 combined, as applied to the composite outcome of death and/or ICU admission within 30 days. Regressors were included if accurate data was available for >80% of the combined pool of 2261 patients. For categorical variables, a positive “estimate” indicates an increased risk of the composite outcome (death or ICU admission) with that variable present, and a negative estimate indicates a reduced risk of the composite outcome if that variable is present. For continuous variables, a positive “estimate” indicates an increased risk of the composite outcome with that variable increasing, and a negative estimate indicates a reduced risk of the composite outcome if that variable is decreasing. The P value is a measure of the confidence of that variable being an independent predictor of the composite outcome corrected for all of the other regressors listed. Bold values are used to highlight variables with significant P‐values.

Abbreviations: CCF, congestive cardiac failure; eGFR, estimated glomerular filtration rate; FiO₂, fraction of inspired oxygen; IHD, ischaemic heart disease; ICU, intensive care unit; OR, odds ratio.

P <0.05;

^**

P <0.01 for the independent logit coefficient or OR.