Skip to main content
. 2022 Apr 22;166(3):327–340. doi: 10.1111/imm.13475

FIGURE 4.

FIGURE 4

SARS‐CoV‐2‐peptide challenge induced immune activation over 9 months post recovery from mild COVID‐19 indicates persistently increased Th1‐directed peptide challenge responses within individuals over 40 years of age. Heat‐map of p‐values of (a) dual‐activation marker‐positive CD4 T cells and with (b) poly‐functional three‐to‐four activation marker‐positive CD4 T cells from individuals either under or over the age of 40 at under 3, 6–9 and 9–12‐month recovery from mild COVID‐19 after 6‐h incubation with SARS‐CoV‐2 N, S1 or S2‐related peptide pools. Positive responses were compared against age‐matched SARS‐CoV‐2 naïve responses using two‐way ANOVA with Tukey's multiple comparison test. Legend shows p‐value scale and exact p‐values are shown within individual boxes. White values denote p‐values above 0.1. Group Under 40 YO <3‐month recovery n = 59, 6–9‐month recovery n = 18, 9–12 months recovery n = 12, SARS‐CoV‐2 naïve n = 121. Group Over 40 YO <3‐month recovery n = 93, 6–9‐month recovery n = 41, 9–12 months recovery n = 31, SARS‐CoV‐2 naïve n = 206