Table 2.

Suggested Criteria for Therapeutic Intensity Thromboprophylaxis for Moderately Ill Patients with COVID-19

Criteria for Potential Disease Progression	Bleeding Risk Factors That Must Not Be Present
Admitted for COVID-19 infection (not an incidental finding)	End stage renal disease on dialysis
Supplemental oxygen requirement	Advanced liver disease or cirrhosis
Elevated d-dimer (> 2–4 times ULN)	Severe thrombocytopenia
	Use of dual antiplatelet therapy
	Need for therapeutic anticoagulation (e.g., atrial fibrillation, mechanical heart valve)
	Severe anemia
	Contraindication to heparin agents or Heparin-inducted thrombocytopenia
	Recent bleeding
	Bleeding disorder

To consider therapeutic intensity thromboprophylaxis for moderately ill patients with COVID-19, they should meet all 3 criteria for disease progression as well as not having any bleeding risk factors. Note that the risk factors listed are not exhaustive

ULN – upper limit of normal