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Correlation between gradient of lesion volume exceeding a given z-score threshold at baseline and EDSS assessed 2 years after baseline (change between bands for z-score thresholds of 0, 1, 2 and 3) in patients with early multiple sclerosis: (A) band 1:5; (B) band 1:10; (C) band 1:20. (* indicates statistically significant values, * p < 0.05 ** p < 0.01).
