Table 4.

A, B Correlation between gradient of lesion volume exceeding a given z-score threshold and EDSS at baseline (A) and correlation between gradient of volume exceeding a given z-score threshold in NAWM at baseline (B) and EDSS assessed 2 years after baseline in patients with early multiple sclerosis (* indicates statistically significant values).

A
	Correlation coefficient for the z-score thresholds				p-values
Gradient between bands	0	1	2	3	0	1	2	3
1–2	0.292	0.279	0.282	0.290	0.047*	0.058	0.055	0.048*
1–5	0.392	0.368	0.374	0.377	0.006*	0.011*	0.010*	0.009*
1–10	0.402	0.396	0.377	0.386	0.005*	0.006*	0.009*	0.007*
1–20	0.389	0.379	0.378	0.375	0.007*	0.009*	0.009*	0.009*
1–30	0.375	0.360	0.365	0.371	0.009*	0.013*	0.012*	0.010*

B
	Correlation coefficient for the z-score thresholds				p-values
Gradient between bands	0	1	2	3	0	1	2	3
1–2	0.219	0.157	0.218	0.198	0.138	0.292	0.142	0.181
1–5	0.216	0.211	0.251	0.237	0.145	0.155	0.089	0.109
1–10	0.143	0.298	0.287	0.253	0.338	0.042*	0.050*	0.087
1–20	0.036	0.336	0.355	0.278	0.808	0.021*	0.014*	0.058
1–30	0.032	0.347	0.355	0.282	0.833	0.017*	0.014*	0.055

EDSS = expanded disability status scale, NAWM = normal appearing white matter.