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. 2022 Apr 22;8(5):1010–1021. doi: 10.1021/acsinfecdis.1c00628

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© 2022 The Authors. Published by American Chemical Society

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Viability of A549 cells treated with 12, 13, 23, and 24 and 15% (v/v) wt PA14 supernatant or ΔlasB PA14 supernatant. (A) Dose-dependent effect of the compounds on the viability of A549 cells treated with wt PA14 supernatant; (B) no effect of the compounds on A549 cells treated with ΔlasB PA14 supernatant. The supernatant-treated groups are shown in gray background. Each graph is a representation of three independent experiments; mean ± SD. One-way ANOVA was performed for each experiment following Dunnett’s multiple comparison test. The mean of each column was compared with the mean of the negative control (ns: not significant, *: p ≤ 0.05, **: p ≤ 0.01, ***:p ≤ 0.001). wt PA14: wild-type Pseudomonas aeruginosa, ΔlasB PA14: LasB knockout P. aeruginosa, Pam: phosphoramidon.