Optimization of reaction conditions with the FC/AC catalyzed 1,5-benzodiazepine synthesis^a.

Entry	Catalyst	Catalyst dosage (wt%)	Conv./sel.b (%)	Yieldb (%)
1	Without catalyst	0	0/0	0
2	5 wt% FC/AC	10	57/87	50
3	10 wt% FC/AC	10	99/91	90
4	15 wt% FC/AC	10	98/91	89
5	20 wt% FC/AC	10	98/92	90
6	10 wt% FC/AC	20	90/94	85
7	10 wt% FC/AC	30	94/93	87

^aReaction conditions: all reactions proceeded with 1 mmol o-phenylenediamine (OPDA), 2.2 mmol ketone, and FC/AC catalyst under solvent-free condition for 8 h.

^bYield refers to isolated product which characterized by ¹H NMR, ¹³C NMR.

^cRelative polarity of the solvents.