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. 2022 May 17;11:29. doi: 10.1186/s40164-022-00282-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Chidamide synergizes with apatinib to abrogate the leukemia burden and prolong the survival in an AML PDX model. A The schematic plan of the in vivo experiment of the AML PDX model. B The spleen image (left panel) and weight (right panel) from the PDX mice treated with distinct groups. C The analysis of human CD45 (hCD45) percentages in bone marrow (BM, left panel), spleen (SP, middle panel), and peripheral blood (PB, right panel) in the four different treatment groups. D Kaplan Meier curve of the primary AML PDX mice administered with Vehicle, apatinib, chidamide and the combined regimen at the planned treatment timepoints. CS055 and Combo mean chidamide and the combination of chidamide and apatinib