Table 2.
Gas exchange and level of ventilatory support within 24 h of commencement of IMV in patients who received or did not receive neuromuscular blocking agents (NMBAs)
| Unmatched cohort (N = 1953) |
Propensity score-matched cohort (N = 420) | |||
|---|---|---|---|---|
| Parameter | Control (N = 1711) |
NMBA treatment (N = 242) |
Control (N = 210) |
NMBA treatment (N = 210) |
| pH mean (SD) | 7.4 (0.1) | 7.3 (0.1) | 7.3 (0.1) | 7.3 (0.1) |
| FiO2 (mmHg) mean (SD) | 76.1 (21.9) | 77.3 (21.9) | 81.0 (20.8) | 77.5 (22.0) |
| PaO2/FiO2 (mmHg) mean (SD) | 98.1 (31.1) | 88.5 (29.3) | 86.0 (30.7) | 88.6 (29.7) |
| PaCO2 (mmHg) mean (SD) | 48.7 (13.5) | 50.9 (13.9) | 48.0 (15.5) | 51.0 (13.7) |
| Tidal volume (ml/PBW) mean (SD) | 7.1 (1.4) | 6.9 (1.4) | 7.4 (1.6) | 6.8 (1.4) |
| Respiratory system compliance (mL/cmH2O) mean (SD) | 33.8 (11.9) | 32.9 (12.7) | 33.9 (12.2) | 32.5 (12.6) |
| Plateau pressure (cmH2O) mean (SD) | 25.4 (5.7) | 26.1 (5.1) | 25.0 (5.9) | 26.2 (5.0) |
| Driving pressure (cmH2O) mean (SD) | 22.8 (7.4) | 22.1 (7.6) | 22.4 (8.6) | 22.7 (7.5) |
| Respiratory rate (breaths/min) mean (SD) | 23.8 (7.0) | 24.5 (7.1) | 24.7 (7.4) | 24.8 (7.3) |
| PEEP level (cmH2O) mean (SD) | 12.0 (3.0) | 12.8 (3.3) | 11.9 (3.1) | 12.8 (3.3) |
| Heart rate (beats/min) mean (SD) | 89.1 (27.4) | 93.9 (29.0) | 90.9 (30.5) | 95.5 (28.4) |
| Mean arterial pressure (mmHg) mean (SD) | 80.9 (19.8) | 77.3 (21.6) | 80.2 (20.2) | 76.7 (21.7) |
NMBA treatment was defined as at least 2 days of continuous use of NMBAs or up to 3 days, within 48 h from commencement of IMV
IMV, invasive mechanical ventilation; FiO2, inspiratory fraction of oxygen; PaO2/FiO2, ratio between arterial partial pressure of oxygen and inspiratory fraction of oxygen; PaCO2, arterial partial pressure of carbon dioxide; PBW, predicted body weight; PEEP, positive end-expiratory pressure