Skip to main content
. Author manuscript; available in PMC: 2023 Jun 15.
Published in final edited form as: Life Sci. 2022 Apr 2;299:120528. doi: 10.1016/j.lfs.2022.120528

Figure 1. Blood glucose is significantly increased in the Akita diabetic mouse relative to nondiabetic controls and this is not effected by genetic deletion of NLRP3.

Figure 1.

Blood glucose levels were assessed at week 30 of life using the AimStrip Plus blood glucose testing system and blood from the submandibular vein. Measurements were taken from all non-fasted animals at approximately the same time of day (between 1 and 2 PM). A. Blood glucose is significantly increased in the diabetic mouse with a NLRP3+/+ genotype. n=32 (nondiabetic), 25 (diabetic). B. Blood glucose is elevated in the diabetic mouse with a NLRP3−/− genotype. n=33 (nondiabetic), 30 (diabetic). For all graphs bars represent the mean ± SEM. ***p<0.0001 by Student’s two tailed t-test. non-diab = nondiabetic. diab = diabetic. ANOVA followed by Student-Newman-Keuls post hoc test was also used to compare all groups. The only additional significant differences found were between nondiabetic/NLRP3+/+ and diabetic/NLRP3−/− as well as diabetic/NLRP3+/+ and nondiabetic/NLRP3−/−. These comparisons can be found in the supplemental material.