TABLE 3.

Cycloserine concentrations in samples collected during operations

Patient ID	Sex	BMI/wt (kg)	Dose/wt	Sampling time after morning dosing (min)	Plasma concn (μg/mL)	Bone concna		Bone/plasma ratio	MIC of cycloserine (μg/mL)
						μg/mL	μg/g
1	Female	24.22/62	8.06	120	12.776	12.839	24.3941	1.00	NA
2	Male	25.50/79	6.33	120	10.555	6.955	13.2145	0.66	NA
3	Male	20.37/66	7.58	130	17.615	11.185	21.2515	0.63	NA
4	Male	19.59/60	8.33	135	21.455	7.375	14.0125	0.34	NA
5	Female	21.48/55	9.09	140	25.030	20.924	39.7556	0.84	16
6	Male	16.44/47.5	10.53	150	12.651	16.067	30.5273	1.27	NA
7	Male	21.89/64	7.81	150	16.322	8.744	16.6136	0.54	NA
8	Female	23.88/65	7.69	150	15.048	7.363	13.9897	0.49	NA
9	Male	24.97/60	8.33	150	30.415	10.613	20.1647	0.35	16
10	Male	26.81/84	5.95	160	14.603	7.522	14.2918	0.52	NA
11	Female	24.03/60	8.33	190	10.815	3.603	6.8457	0.33	16
12	Female	23.23/58	8.62	200	14.671	22.241	42.2579	1.52	16
13	Female	20.76/60	8.33	200	16.814	6.611	12.5609	0.39	16
14	Male	15.94/45	11.11	210	31.675	19.710	37.449	0.62	NA
15	Male	18.19/57	8.77	220	18.329	15.009	28.5171	0.82	16
16	Female	20.94/57	8.77	220	20.029	14.046	26.6874	0.70	NA
17	Male	22.31/66	7.58	245	16.256	17.094	32.4786	1.05	16
18	Female	22.83/57	8.77	260	13.495	26.778	50.8782	1.98	16
19	Male	20.76/60	8.33	260	19.762	10.225	19.4275	0.52	NA
20	Female	24.84/62	8.06	260	17.149	10.433	19.8227	0.61	16
21	Male	24.82/76	6.58	260	15.471	14.187	26.9553	0.92	NA
22	Female	26.12/80	6.25	280	23.092	29.055	55.2045	1.26	NA
23	Male	15.04/45	11.11	280	13.504	11.204	21.2876	0.83	16
24	Female	19.98/48	10.42	280	8.845	12.011	22.8209	1.36	NA
25	Female	18.03/45	11.11	300	19.414	19.836	37.6884	1.02	NA
26	Male	17.99/52	9.62	315	24.241	13.826	26.2694	0.57	16
27	Male	19.27/59	8.47	330	8.871	12.769	24.2611	1.44	16
28	Male	20.68/67	7.46	420	14.421	15.808	30.0352	1.10	NA

^aBone concentrations are reported in micrograms per gram by multiplying by a conversion factor of 1.9 g/mL for bone density (17). NA, not applicable.