TABLE 1.
MICs of metronidazole, clindamycin, and PM-477 for Gardnerella type strains and patient isolatesa
| Species (no. of isolates) | Antimicrobial agent | MIC (μg/mL) |
No. (%) resistant | |
|---|---|---|---|---|
| Range | MIC90 | |||
| G. vaginalis (8) | MDZ | 8 to 64 | 64 | 2 (25) |
| CLI | <0.06 to 0.5 | 0.5 | 0 | |
| PM-477 | <0.03 to 0.5 | 0.5 | ND | |
| G. leopoldii (3) | MDZ | 128 to >256 | >256 | 3 (100) |
| CLI | 0.5 | 0.5 | 0 | |
| PM-477 | 0.125 to 0.5 | 0.5 | ND | |
| G. piotii (7) | MDZ | 8 to 128 | 128 | 4 (57) |
| CLI | 0.125 to 2 | 2 | 0 | |
| PM-477 | 0.5 to 1 | 1 | ND | |
| G. swidsinskii (4) | MDZ | 64 to >256 | >256 | 4 (100) |
| CLI | <0.06 to 0.5 | 0.5 | 0 | |
| PM-477 | 0.03 to 0.25 | 0.25 | ND | |
| All Gardnerella (22) | MDZ | 8 to >256 | >256 | 13 (59) |
| CLI | <0.06 to 2 | 0.5 | 0 | |
| PM-477 | <0.03 to 1 | 1 | ND | |
a
Resistance is defined as ≥32 μg/mL and ≥8 μg/mL for metronidazole (MDZ) and clindamycin (CLI), respectively. The MIC90 is defined as the MIC value for 90% of the tested strains. For PM-477, the resistance breakpoint is not defined; therefore, a percentage of isolates resistant is not defined (ND).