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. 2022 Apr 13;66(5):e02319-21. doi: 10.1128/aac.02319-21

TABLE 3.

Susceptibility of Gardnerella strains before and after passaging 8 to 9 times with sub-MICs of MZD or MDZ-OHa

Gardnerella strain Passaging antibiotic MIC (μg/mL)
MBEC (μg/mL) when passaged with:
Before passaging
After passaging
MDZ MDZ-OH PM-477 MDZ MDZ-OH PM-477 MDZ PM-477
G. vaginalis
 ATCC 14018T MDZ 8 2 0.06 >512 >512 0.13 >2,048 2–8
 UGent 09.07b MDZ-OH 64 8 0.25 >2,048 >512 0.25 >2,048 2–4
 UGent BV50 MDZ-OH 32 4 0.5 >2,048 >512 0.25 >2,048 1–8
G. swidsinskii
 GS 9838-1T MDZ-OH 256 16 0.03 >512 >512 0.06 >2,048 2
 UGent BV 7.1 MDZ-OH 256 32 0.25 >2,048 >512 0.06 >2,048 2
G. piotii UGent 18.01T MDZ-OH 32 8 1 >2,048 >512 2 >2,048 <1
a

All MICs were determined after 48 h of incubation. MBEC, minimal biofilm radication concentration; MDZ, metronidazole; MDZ-OH, hydroxy metabolite of MDZ; T, after strain designation indicates a type strain.

b

G. vaginalis UGent 09.07 was passaged only 8 times with MDZ-OH.