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TBP PK parameters for cohort 4 subjects with estimated creatinine clearances of <20 mL/min and ≥20 mL/min
| PK parameter | Result for cohort 4a |
|
|---|---|---|
| CLCR of <20 mL/min (n = 4) | CLCR of ≥20 mL/min (n = 4) | |
| AUC0–∞ (μg · h/mL) | 183.0 (111.0, 389.0) | 60.5 (49.4, 82.8) |
| t1/2 (h) | 5.1 (4.2, 6.5) | 2.0 (1.5, 2.6) |
| CL/F (L/h) | 3.3 (1.2, 4.2) | 8.0 (5.6, 9.4) |
| CLR (L/h) | 0.9 (0.3, 1.5) | 3.9 (2.5, 5.1) |
The arithmetic mean (minimum, maximum) is presented. CLCR, estimated creatinine clearance.
