TABLE 4.
Excretion of TBP in urine and renal clearance for cohorts 1 to 4
| PK parametera | Result for: |
|||
|---|---|---|---|---|
| Cohort 1 (normal [n = 7]) | Cohort 2 (mild RI [n = 7])b | Cohort 3 (moderate RI [n = 8]) | Cohort 4 (severe RI [n = 8]) | |
| Ae% | 62.2 ± 17.5 | 63.9 ± 11.9 | 55.4 ± 17.0 | 38.3 ± 16.9 |
| Aeu (mg) | 288 ± 81.0 | 295 ± 55.0 | 256 ± 78.7 | 177 ± 77.9 |
| CLR (L/h) | 13.4 ± 3.44 | 10.0 ± 3.06 | 5.63 ± 2.15 | 2.40 ± 1.82 |
a
Ae%, percentage excreted of TBP equivalent dose administered; Aeu, cumulative amount of drug excreted in urine.
b
One subject in cohort 2 did not have a urine sample available during the first collection period (0 to 4 h postdose).