TABLE 3.
Clinical characteristics and outcomes of patients with CRAB infections by treatment regimensa
| Variable | FDC-containing regimens (N = 47) | Colistin-containing regimens (N = 77) | p b |
|---|---|---|---|
| Age, median, IQRs | 63 (53.5–75) | 68 (56–75) | 0.414 |
| Male sex | 29 (61.7%) | 63 (81.8%) | 0.013 |
| Comorbidities | |||
| Diabetes mellitus | 3 (6.4%) | 20 (26%) | 0.006 |
| Cardiovascular disease | 29 (61.7%) | 44 (57.1%) | 0.617 |
| COPD | 4 (8.5%) | 13 (16.9%) | 0.188 |
| Chronic renal disease | 2 (4.3%) | 7 (9.1%) | 0.314 |
| Chronic liver disease | 2 (4.3%) | 3 (3.9%) | 1.0 |
| Solid cancer | 3 (6.4%) | 5 (6.5%) | 0.981 |
| COVID-19 | 19 (40.4%) | 29 (37.7%) | 0.759 |
| Ward of hospitalization | |||
| Medical wards | 4 (8.5%) | 8 (10.4%) | 0.731 |
| Surgery | 1 (2.1%) | 0 | 0.199 |
| ICU | 42 (89.4%) | 69 (89.6%) | 0.965 |
| Type of infections | |||
| BSI | 27 (57.4%) | 52 (67.5%) | 0.257 |
| VAP | 12 (25.5%) | 23 (29.9%) | 0.603 |
| Other | 8 (17%) | 2 (2.6%) | 0.006 |
| Charlson Comorbidity Index, median, IQRss | 3 (1–5) | 3 (1–5) | 0.413 |
| SOFA score, median, IQRs | 9 (6–11) | 9 (4–11) | 0.693 |
| APACHE II score, median, IQRs | 18 (9–25) | 16 (11–22) | 0.702 |
| Invasive mechanical ventilation | 25 (53.2%) | 45 (55.8%) | 0.459 |
| Intravascular device | 47 (100%) | 77 (100%) | 1.0 |
| Septic shock | 30 (63.8%) | 45 (58.4%) | 0.551 |
| AKI at time of sepsis | 10 (21.3%) | 21 (27.3%) | 0.454 |
| Parenteral nutrition | 20 (42.6%) | 19 (24.7%) | 0.038 |
| ECMO at time of sepsis | 7 (14.9%) | 2 (2.6%) | 0.026 |
| CVVH at time of sepsis | 6 (12.8%) | 8 (10.5%) | 0.704 |
| Source control | 18 (38.3%) | 31 (40.3%) | 0.828 |
| Polymicrobial infections | 8 (17%) | 22 (28.6%) | 0.145 |
| Duration of targeted antibiotic therapy | 12 (7–14) | 10 (6.5–13) | 0.089 |
| 30-day mortality | 16 (34%) | 43 (55.8%) | 0.018 |
| Microbiological failurec | 8/46 (17.4%) | 5/74 (6.8%) | 0.079 |
| Length of hospital stay after CRAB infection, median, IQRs | 28 (16–34) | 13 (6–23.5) | <0.001 |
a
AKI: acute kidney injury; BSI: bloodstream infections; FDC: cefiderocol; ECMO: extra corporeal membrane oxygenation; CVVH: continuous veno-venous hemofiltration; ICU: intensive care units; IQRs: interquartile ranges; VAP: ventilator-associated pneumonia.
b
Boldface italic entries are statistically significant (P < 0.05).
c
Microbiological failure available on 120/124 patients who had follow-up cultures available.