Table 3.

Multiple regression results of gray, white, and white matter hyperintensity (WMH) volumes predicting cerebrospinal fluid (CSF) neurofilament light (NfL). Age, sex, race, and total intracranial volume (ICV) were included as covariates.

WMH Volume
	t	β (SE)	p
WMH	4.32	0.24 (16.77)	<0.001
Age	8.59	0.42 (1.84)	<0.001
Sex	−4.15	−0.22 (32.08)	<0.001
Race	−2.34	−0.10 (45.70)	0.02
ICV	−1.19	−0.07 (0.00)	0.23
Gray matter volume
Gray Matter	−2.38	−0.15 (20.70)	0.02
Age	9.90	0.48 (1.86)	<0.001
Sex	−2.94	−0.15 (32.00)	<0.001
Race	−2.25	−0.09 (45.20)	0.03
ICV	2.83	0.19 (0.00)	<0.001
White matter volume
	t	β (SE)	p
White Matter	−1.23	−0.08 (20.79)	0.22
Age	10.83	0.51 (1.82)	<0.001
Sex	−2.66	−0.13 (32.01)	0.01
Race	−1.90	−0.07 (45.15)	0.06
ICV	2.18	0.15 (0.00)	0.03
WMH + Gray + White Matter Volumes
WMH	3.94	0.22 (17.25)	<0.001
Gray Matter	−1.27	−0.10 (23.77)	0.20
White Matter	−0.10	−0.01 (22.45)	0.92
Age	6.76	0.38 (2.14)	<0.001
Sex	−4.13	−0.22 (32.27)	<0.001
Race	−2.46	−0.10 (46.47)	0.01
ICV	0.30	0.03 (0.00)	0.77