Table 5.
Percentage of CD28null CD8+ T and NKT-like cells producing interferon gamma (IFNγ) and tumour necrosis factor alpha (TNF α) in blood, BAL, SA, and LA from patients with the COPD and control subjects
| COPD | T cells | NKT-like cells | ||
|---|---|---|---|---|
| CD28null CD8+ | CD28null CD8+ | |||
| IFNγ | TNFα | IFNγ | TNFα | |
| Blood | ^55 (38–63)# | ^58 (42–66) | ^61 (36–71) | ^66 (38–73) |
| BAL | ^62 (42–76) | ^59 (39–73) | ^67 (48–91) | ^69 (41–78) |
| LA | ^72 (54–92) | ^67 (51–88) | ^74 (42–79) | ^78 (52–84) |
| SA | ^86 (69–98)@ | ^92 (72–97)@ | ^88 (71–99)@ | ^91 (69–96)@ |
| Control | T cells | NKT-like cells | ||
| CD28null CD8+ | CD28nullCD8+ | |||
| IFNγ | TNFα | IFNγ | TNFα | |
| Blood | 34 (18–42) | 36 (20–45) | 36 (23–44) | 35 (16–48) |
| BAL | 33 (13–46) | 33 (12–33) | 36 (18–53) | 36 (13–46) |
| LA | 31 (12–43) | 39 (14–41) | 33 (16–47) | 37 (13–51) |
| SA | 38 (22–53) | 31 (12–38) | 42 (25–62) | 30 (11–40) |
There was a significant increase in CD28null CD8+ T and NKT-like cells producing IFNγ and TNFα in blood, BAL, SA, and LA from patients with the COPD compared with control subjects. There was a significant increase in CD28null CD8+ T and NKT-like cells producing IFNγ and TNFα in SA compared with blood, BAL, and LA from patients with the COPD.
Median (range).
Significantly increased compared with control (P < 0.05 for all).
Significantly increased compared with blood, BAL and LA (P < 0.05 for all).