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. 2022 Apr 12;6(6):bvac062. doi: 10.1210/jendso/bvac062

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Schematic diagram of the gene locus of human and mouse 21-hydroxylase. The CYP21A2/Cyp21a1 gene and its related pseudogene CYP21A1P/Cyp21a2-p are located in the major histocompatibility (MHC) locus neighboring 3 other genes which are serine/threonine kinase 19 (STK19/Stk19), complement C4A/C4a and C4B/C4b as well as tenascin-X A and B (TNXA/B, Tnxa/b). The mouse locus on chromosome 17 have the same gene duplication cassette as the human locus on chromosome 6 except the extra pseudogene superkiller viralicidic activity 2-like (Skiv2l-ps1). Pseudogenes are framed in red. Arrows mark the reading direction of the genes.