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. 2022 Apr 16;6(6):bvac065. doi: 10.1210/jendso/bvac065

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Change in serum 25(OH)D concentration after 3 months of vitamin D supplementation. (A) Histogram of absolute change in serum 25(OH)D concentration in 637 participants 3 months after randomization to the vitamin D study pill (dose 200, 1000, 2000, or 4000 IU/day). Absolute change in serum 25(OH)D was calculated as concentration at 3 months minus concentration at baseline. Changes were sorted into bins of width 5 ng/mL. To convert 25(OH)D ng/ml to nmol/L multiply the ng/ml by 2.5. (B) Histogram of relative (%) change in serum 25(OH)D in 637 participants 3 months after randomization to the vitamin D study pill (dose 200, 1000, 2000, or 4000 IU/day). Relative change in serum 25(OH)D was calculated as (concentration at 3 months minus concentration at baseline) divided by concentration at baseline. Fifty-eight participants had a percent decrease (3% to 36%), 27 participants had no change, and 552 participants had a percent increase in serum 25(OH)D at 3 months relative to baseline. The x-axis uses a log scale.