Efficacy analyses (intent-to-treat population) showing (A) Kaplan-Meier estimate of final OS analysis, (B) forest plot of OS subgroup analyses, (C) Kaplan-Meier estimates of time to first subsequent antineoplastic therapy, and (D) Kaplan-Meier estimates of rPFS (investigator assessed). ADT, androgen deprivation therapy; E, events; ECOG, Eastern Cooperative Oncology Group; ENZA, enzalutamide; HR, hazard ratio; NE, not evaluable; NR, not reached; OS, overall survival; PBO, placebo; PSA, prostate-specific antigen; RoW, rest of world; rPFS, radiographic progression-free survival.