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. 2022 May 3;13:874792. doi: 10.3389/fimmu.2022.874792

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Copyright © 2022 Dong, Gu, Shi, Bao, Fu, Fang, Qu, Zhu, Jiang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of m⁷G subtypes of ccRCC. (A) Consensus matrix of samples in TCGA-ccRCC for k=3. (B) The number of optimum clusters is determined by the lowest proportion of ambiguous clustering. (C) The cumulative distribution function curves for k = 2 to 9. (D) The principal component plot is based on m⁷G -related genes. (E, F) Kaplan-Meier survival analysis for overall survival (left) and progression-free interval (right) of the three subtypes in TCGA-ccRCC dataset. (G) The expression profiles of the m⁷G regulators in three subtypes and normal kidney samples. ****P < 0.0001.