Figure 1.

Relative expression of bile acid synthesis and transport genes in ff Shp and LShpKO mice on chow and 1% CA diets. (A-B) Expression of key bile acid synthesis genes, and (C-F) Expression of hepatic bile acid uptake and canalicular bile acid export pumps, (G) Western blot analysis of proteins responsible for classical bile acid synthesis. One-way ANOVA analysis of variance Bonferroni test was used to determine significance between groups. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001.