Figure 5.

Characterization of Car-mediated proliferation in LShpKO mice. (A) Ki-67 immunohistochemistry of liver tissue samples showing proliferation of hepatocytes and nonparenchymal cells (NPCs) treated with TC. (B) Quantification of proliferating hepatocytes. Quantification of proliferating NPCs. (C) Relative expression of several cyclins involved in the progression of the cell cycle. One-way ANOVA analysis of variance Bonferroni test was used to determine significance between 2 groups under 2 conditions. Two-tailed unpaired t test was used to determine significance between 2 groups. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001.