Table 3.
Post Hoc Multivariate Multiple Linear Regression Model
| β | SE | t-value | P-value | |
|---|---|---|---|---|
| Model 3a | ||||
| Visuomotor processing speed (F(5, 33) = 5.079, P < .01*, adjusted R2 = .349)a | ||||
| Intercept | −1.100 | 0.295 | −3.728 | .001* |
| Education | 0.274 | 0.062 | 4.407 | .000* |
| Tumor location | −0.389 | 0.370 | −1.051 | .301 |
| GTV | −0.001 | 0.001 | −1.794 | .082 |
| Dorsal frontal | 0.001 | 0.000 | 2.190 | .036* |
| Parietal-occipital | −1.100 | 0.437 | −2.516 | .017* |
| Executive function (F(5, 33) = 3.396, P < .05*, adjusted R2 = .240) | ||||
| Intercept | −0.623 | 0.165 | −3.786 | .001* |
| Education | 0.116 | 0.035 | 3.347 | .002* |
| Tumor location | −0.378 | 0.200 | −1.892 | .067 |
| GTV | 0.000 | 0.000 | −0.267 | .791 |
| Dorsal frontal | 0.000 | 0.000 | 0.560 | .579 |
| Parietal-occipital | −0.076 | 0.206 | −0.366 | .717 |
| Memory (F(5,33) = 1.319, P = .280, adjusted R2 = .040) | ||||
| Attention/working memory (F(5,33) = 0.776, P = .574, adjusted R2 = .030) | ||||
| Model 3b | ||||
| Visuomotor processing speed (F(5,33) = 5.064, P < .01*, adjusted R2 = .348) | ||||
| Intercept | −1.029 | 0.300 | −3.431 | .002* |
| Education | 0.266 | 0.066 | 4.043 | .000* |
| Tumor location | −0.183 | 0.346 | −0.527 | .601 |
| GTV | −0.001 | 0.001 | −0.988 | .330 |
| Dorsal frontal | 0.459 | 0.347 | 1.321 | .196 |
| Parietal-occipital | −0.697 | 0.346 | −2.013 | .049* |
| Executive function (F(5,33) = 3.453, P < .05*, adjusted R2 = .244 | ||||
| Intercept | −0.622 | 0.162 | −3.836 | .001* |
| Education | 0.114 | 0.036 | 3.192 | .003* |
| Tumor location | −0.377 | 0.187 | −2.013 | .048* |
| GTV | 0.000 | 0.000 | −0.239 | .812 |
| Dorsal frontal | 0.123 | 0.188 | 0.654 | .517 |
| Parietal-occipital | −0.121 | 0.187 | −0.648 | .521 |
| Memory (F(5,33) = 1.089, P = .385, adjusted R2 = .011) | ||||
| Attention/working memory (F(5,33) = 0.619, P = .686, adjusted R2 = .053) |
Neurocognitive factors were the outcome variables. Model 3a represents mean dose and Model 3b represents dose to 50% of the region (D50). Only the visuomotor processing speed and executive function factors were significant, and thus individual ROI’s are presented. Memory and attention/working memory factors were not significant and thus ROI’s cannot be interpreted and are not presented. Surgical resection (Y/N) was not related to our outcomes and therefore not included in Model 2. Analyses excluding the 11 participants who did not have surgery are provided in Supplementary Table 4. The pattern of results tended to be consistent with the findings above.
Abbreviations: SE, standard error; GTV, gross tumor volume.
*Significant P-values (<.05).
aAdjusted R2 values of <.13 represent weak associations, ≥.13 and <.26 represent moderate associations, and ≥.26 represent substantial associations.54