Table 1.
Characteristics of Patients Aged <18 Years Diagnosed With a CNS Tumor in the Netherlands Between 1990 and 2017
| Overall | Malignant Tumors (Excl. Pilocytic Astrocytomas) | Pilocytic Astrocytomas (9421/1, 9421/3, 9425/3a) | Nonmalignant Tumors (Excl. Pilocytic Astrocytomas)b | |
|---|---|---|---|---|
| (N = 3637) | (N = 2057) | (N = 885) | (N = 695) | |
| Sex | ||||
| Boys | 1934 (53.2%) | 1198 (58.2%) | 429 (48.5%) | 307 (44.2%) |
| Girls | 1703 (46.8%) | 859 (41.8%) | 456 (51.5%) | 388 (55.8%) |
| Age at diagnosis (in years) | ||||
| 0 | 183 (5.0%) | 129 (6.3%) | 29 (3.3%) | 25 (3.6%) |
| 1-4 | 893 (24.6%) | 555 (27.0%) | 236 (26.7%) | 102 (14.7%) |
| 5-9 | 1039 (28.6%) | 601 (29.2%) | 299 (33.8%) | 139 (20.0%) |
| 10-14 | 923 (25.4%) | 509 (24.7%) | 207 (23.4%) | 207 (29.8%) |
| 15-17 | 599 (16.5%) | 263 (12.8%) | 114 (12.9%) | 222 (31.9%) |
| Period of diagnosis | ||||
| 1990-1999 | 932 (25.6%) | 688 (33.4%) | 244 (27.6%) | |
| 2000-2009 | 1435 (39.5%) | 721 (35.1%) | 361 (40.8%) | 353 (50.8%) |
| 2010-2017 | 1270 (34.9%) | 648 (31.5%) | 280 (31.6%) | 342 (49.2%) |
| ICCC-3 Diagnostic groups | ||||
| (IIIa) Ependymomas and choroid plexus tumors | 340 (9.3%) | 272 (13.2%) | 68 (9.8%) | |
| (IIIb) and (IIId) Astrocytomas and other gliomas | 1755 (48.3%) | 839 (40.8%) | 885 (100%) | 31 (4.5%) |
| (IIIc) Intracranial and intraspinal embryonal tumors | 616 (16.9%) | 616 (29.9%) | ||
| (IIIe) Other specified intracranial and intraspinal neoplasms | 587 (16.1%) | 43 (2.1%) | 544 (78.3%) | |
| (IIIf) Unspecified intracranial and intraspinal neoplasms | 213 (5.9%) | 161 (7.8%) | 52 (7.5%) | |
| (Xa) Intracranial and intraspinal germ cell tumors | 126 (3.5%) | 126 (6.1%) | ||
| WHO grade | ||||
| I | 1501 (41.3%) | 21 (1.0%) | 871 (98.4%) | 609 (87.6%) |
| II | 495 (13.6%) | 448 (21.8%) | 14 (1.6%) | 33 (4.7%) |
| III | 275 (7.6%) | 275 (13.4%) | ||
| IV | 805 (22.1%) | 805 (39.1%) | ||
| Germ cell tumors | 126 (3.5%) | 126 (6.1%) | ||
| Unknown | 435 (12.0%) | 382 (18.6%) | 53 (7.6%) | |
| Microscopic verification | ||||
| No | 667 (18.3%) | 387 (18.8%) | 96 (10.8%) | 184 (26.5%) |
| Yes | 2970 (81.7%) | 1670 (81.2%) | 789 (89.2%) | 511 (73.5%) |
aPilomyxoid astrocytoma n = 14, between 2005 and 2016.
bNonmalignant tumors were registered since the year 2000.