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. 2022 May 9;15:4781–4791. doi: 10.2147/IJGM.S363425

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© 2022 Wu et al.

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Size distribution of eccDNA. (A) Size distribution of plasma eccDNA in 6 lung adenocarcinoma cases. Plasma samples of 6 lung adenocarcinoma cases were analyzed and displayed with different colors. Plasma eccDNA length in most samples showed similar bimodal peak distribution, indicating that eccDNA in plasma of lung adenocarcinoma patients was quite regular. (B) Cumulative frequency plots of plasma eccDNA length from 6 lung adenocarcinoma cases. More than 90% plasma eccDNA in 6 lung adenocarcinoma cases were smaller than 800 bp. (C) Size distribution of total eccDNA in plasma of adenocarcinoma patients (group (A)), healthy pregnant women (group (B)), and healthy adults (group (C)). The size of eccDNA is represented by the abscissa, while the number of eccDNA is shown by the ordinate. The size of eccDNA in groups A and B showed distinct bimodal peak distribution at ~190bp and ~330bp, with evident 10-bp periodicity around the two peaks. Plasma eccDNA counts in group C were smaller compared with other groups and no prominent size distribution characteristics was noticed. (D) Cumulative frequency plots of plasma eccDNA in adenocarcinoma patients (group (A)), healthy pregnant women (group (B)), and healthy adults (group (C)). Group (A) and group (B) showed similar bimodal peak distribution.