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. 2022 Mar 10;225(10):1811–1821. doi: 10.1093/infdis/jiac079

Figure 5.

Figure 5.

The effect of heme on the outcome of invasive pulmonary aspergillosis. (A and B) Survival of neutropenic mice, intratracheally challenged with indicated inocula. n = 6–23 per group, combined from 2 experiments. (C) Bronchoalveolar lavage (BAL) supernatant heme content in neutropenic mice on day 3 of infection. (D and E) Lung fungal content measured as lung colony-forming units and BAL fluid β-glucan content in neutropenic mice on day 3 of infection. (F) Extent of lung injury, as measured by BAL fluid albumin content, in neutropenic mice on day 3 of infection. Data in C–F represent mean ± standard error of the mean of n = 4–15 animals in each panel, combined from 3 experiments. *, **, and **** denote P < .05, P < .01, and P < .0001, respectively. NS, no significant difference.