Figure 6.

The effect of fungal heme exposure on severity of invasive aspergillosis. Lung fungal content measured as lung colony-forming units (A) and bronchoalveolar lavage (BAL) fluid β-glucan content (B), and extent of lung injury, as measured by BAL fluid albumin content (C) in neutropenic mice on day 2 after intratracheal challenge with Aspergillus germlings that were culture in minimal media supplemented with tin(IV)-protoporphyrin or heme. Data represent mean ± standard error of the mean of n = 5–9 animals per group, combined from 2 experiments. * and **** denote P < .05 and P < .0001, respectively.