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. Author manuscript; available in PMC: 2022 May 17.
Published in final edited form as: Am Soc Clin Oncol Educ Book. 2022 Apr;42:1–15. doi: 10.1200/EDBK_351231

FIGURE 2. Immunohistochemical Markers in the Diagnostic Work-Up of Gastrointestinal Stromal Tumor.

FIGURE 2.

(A–C) Example of a KIT-mutant GIST with typical spindle-cell morphology (A) and strong and diffuse expression of KIT (B) and DOG-1 (C). (D–F) In contrast, a PDGFRA-mutant GIST displays epithelioid morphology (D) and weak expression of KIT (E), but strong and diffuse staining for PDGFRA (F). (G–I) Example of an SDH-deficient GIST characterized by epithelioid morphology (G), strong expression of KIT (H), and loss of SDHB expression in tumor cells (I), whereas SDHA expression is retained (I, inset), suggestive of an underlying mutation inactivating SDHB, SDHC, or SDHD.

Abbreviations: GIST, gastrointestinal stromal tumor; SDH, succinate dehydrogenase.