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. Author manuscript; available in PMC: 2022 May 17.
Published in final edited form as: Am Soc Clin Oncol Educ Book. 2022 Apr;42:1–15. doi: 10.1200/EDBK_351231

TABLE 2.

Overview of the National Comprehensive Cancer Network20 Criteria for Risk Assessment in Gastrointestinal Stromal Tumor

Mitotic Index (per 50 HPFs) Tumor Parameter
Risk of Progressive Disease (%)
Size (cm) Gastric (%) Duodenum Jejunum/Ileum Rectum
≤ 5 ≤ 2 0 (none) 0 (none) 0 (none) 0 (none)

≤ 5 > 2 to ≤ 5 1.9 (very low) 4.3 (low) 8.3 (low) 8.5 (low)

≤ 5 > 5 to ≤ 10 3.6 (low) 24 (moderate) Insufficient data Insufficient data

≤ 5 > 10 10 (moderate) 52 (high) 34 (high) 57 (high)

> 5 ≤ 2 None* High* Insufficient data 54 (high)

> 5 > 2 to ≤ 5 16 (moderate) 73 (high) 50 (high) 52 (high)

> 5 > 5 to ≤ 10 55 (high) 85 (high) Insufficient data Insufficient data

> 5 > 10 86 (high) 90 (high) 86 (high) 71 (high)

Abbreviation: HPF, high-power field.

*

Small numbers of cases.